Ingredient Profile
Sodium Hyaluronate
Deep hydration support for skin health and healthy aging.
A highly functional form of hyaluronic acid that helps support skin hydration, elasticity, and barrier function. Supported by human clinical research demonstrating improvements in key skin-health parameters with oral supplementation.
Overview
Sodium hyaluronate is the sodium salt form of hyaluronic acid (HA), supplied across a wide range of molecular-weight grades depending on the intended application. Industry convention generally classifies HA as high molecular weight (>1,800 kDa), middle molecular weight (1,000,000–1,800,000 Da), low molecular weight (400,000–1,000,000 Da), and extra-low/small molecular weight (under 400,000 Da), each suited to different delivery formats.
As a sodium hyaluronate supplier across pharma and cosmetic grades, Probionyx sources HA matched to its intended use: high molecular-weight grades for topical cosmetic formulations targeting surface hydration and a smoothing effect; medical/pharma grades (roughly 800,000–1,300,000 Da) for ophthalmic and dermal applications; and oral-supplement grades, where industry guidance generally favors a higher average molecular weight (around 1,000–3,000 kDa) over very low molecular weight HA, since some research has raised questions about low molecular-weight HA's inflammatory signalling potential when used orally.
Human clinical research on oral sodium hyaluronate supplementation has reported improvements in key skin-health parameters, supporting its position in beauty-from-within and healthy-aging categories, often alongside collagen peptides or other skin-support actives.
Specifications
- Chemical form
- Sodium hyaluronate (sodium salt of hyaluronic acid)
- Molecular weight grades
- High (>1,800 kDa), Middle (1,000–1,800 kDa), Low (400–1,000 kDa), Extra-low (<400 kDa)
- Cosmetic grade
- Typically >1,800 kDa for topical skincare formulations
- Medical/pharma grade
- ~800–1,300 kDa for ophthalmic and dermal applications
- Oral-supplement grade
- Generally higher molecular weight (~1,000–3,000 kDa) preferred over very low MW for oral use
- Format
- Fine white powder, water-soluble
Formulation benefits
- Supports skin hydration and moisture retention
- Helps maintain skin elasticity and healthy appearance
- Suitable for beauty-from-within and healthy-aging formulations
Applications
Frequently asked questions
What's the difference between high and low molecular weight sodium hyaluronate?
Higher molecular-weight HA forms a thicker, more surface-hydrating film and is generally preferred for cosmetic and oral-supplement use. Lower molecular-weight HA penetrates more deeply into skin layers in topical applications, but some research suggests caution around using very low molecular-weight HA in oral formats.
What grade of sodium hyaluronate is best for oral supplements?
Industry guidance generally favors a higher average molecular weight (roughly 1,000–3,000 kDa) for oral hyaluronic acid supplements, since very low molecular-weight HA has been associated in some research with pro-inflammatory signalling.
Is sodium hyaluronate used in both skincare and supplements?
Yes — it's one of the few ingredients supplied across cosmetic (topical), pharmaceutical (medical-grade), and oral-supplement grades, with the appropriate molecular weight selected for each application.
Can sodium hyaluronate be combined with collagen peptides?
Yes, it's commonly formulated alongside collagen peptides in beauty-from-within products, since the two ingredients target complementary aspects of skin hydration and structure.
Talk to our ingredient specialists
Ready to formulate with Sodium Hyaluronate?
Reach out for samples, technical documentation, pricing, and regulatory guidance to bring your formulation to market.